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Patients with severe allergic rhinitis may encounter an elevated risk of developing asthma and other associated allergic conditions. It is known that "allergic rhinitis" and "allergic rhinitis + asthma" are two clinically distinct phenotypes of allergic rhinitis. Consequently, the aim of our study was to establish the diagnostic criteria for the progression of the allergic phenotype in children with...
Kryuchko, Tetyana O. et al.
Italian Journal of Pediatrics. Volume 52(1).
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Kryuchko, Tetyana O. et al.
Italian Journal of Pediatrics. Volume 52(1).
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The cerebellum contributes to the control of movement, language, and sociability. Purkinje cells, the main output neurons of the cerebellar cortex, are reduced in cerebellar malformations (CMs) and in autism spectrum disorder (ASD). Thus, CMs may increase the risk for ASD. We conducted a meta-analysis to determine the prevalence of ASD in individuals with CMs. We searched PubMed, Embase, and APA PsycINFO...
Wells, Douglas A. et al.
Journal of Neurodevelopmental Disorders. Volume 18(1).
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Wells, Douglas A. et al.
Journal of Neurodevelopmental Disorders. Volume 18(1).
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The protein phosphatase PPP4C has been implicated in oncogenic processes, but its role in thyroid carcinoma (THCA) and triple-negative breast cancer (TNBC) remains unclear. Here, we combined bioinformatic analyses with in vitro experiments to investigate the clinical and functional significance of PPP4C in these malignancies. PPP4C was significantly upregulated in both THCA and TNBC compared with normal...
Li, Huashui et al.
BMC Cancer. Volume 26(1).
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Li, Huashui et al.
BMC Cancer. Volume 26(1).
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The present study aimed to investigate the familial, environmental, and pregnancy-related factors associated with anorectal malformations (ARM) in newborns in Pakistan.
Methods: A hospital-based case-control study was conducted at a tertiary referral hospital in the Rawalpindi-Islamabad region between January and July 2025. This study assessed maternal, paternal, and environmental risk factors associated...
Asim, Maleha et al.
BMC Pediatrics. Volume 26(1).
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Asim, Maleha et al.
BMC Pediatrics. Volume 26(1).
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