Acute graft-versus-host disease (aGVHD) is a common complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT) [1]. Systemic corticosteroids are considered the standard initial treatment for aGVHD [2–5]. However, steroid refractoriness occurs in more than 40% of patients and is associated with a dismal prognosis [6–8]. Ruxolitinib, an oral selective inhibitor of...

Jiang Erlie et al.
BMC Medicine 2024; 22(1): 555
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Iliac crest bone graft harvesting is commonly used for various reconstructive surgeries as a source of cortical and cancellous bone [1]. Anterior iliac crest (AIC) is frequently used as a donor site while the patient is in the supine position to provide better outcomes. It may lead to severe postoperative pain, which increases morbidity [2, 3]. In addition, pain at the donor site can be worse than...

Yörükoğlu Hadi Ufuk et al.
BMC Anesthesiology 2024; 24(1): 443
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Kidney transplantation is the treatment of choice for patients with end-stage kidney disease (ESKD) secondary to thrombotic microangiopathy (TMA) [1]. TMA is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, organ ischemia, and dysfunction due to microvascular thrombosis [2]. Post-transplant TMA is a well-recognized complication that affects 0.8 -15% of renal...

Haq Kanza et al.
BMC Nephrology 2024; 25(1): 433
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