À LA UNE de la Rhumatologie
-
The gut-joint axis in juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is an umbrella term for a group of oligo- and poly-arthritic conditions that develop before 16 years of age. While the exact pathophysiology of JIA is still unknown, both genetic and environmental factors are known to contribute to the development and severity of all JIA subtypes. Of the possible environmental factors involved, there is growing evidence that changes... Lire la suite
Arthritis Research & Therapy. Volume 28(1)....
-
Bone marrow mesenchymal stem cell-derived exosomes improve pyroptosis and mitochondrial integrity through miR-515-5p-mediated TLR4/NLRP3/GSDMD axis in...
Bone marrow mesenchymal stem cell (BMSC) therapy can significantly improve the outcomes of rheumatoid arthritis (RA). This study explores the protective role of BMSC-derived exosomes (BMSCs-Exos) in RA through modulation of pyroptosis and mitochondrial integrity via the microRNA (miR)-515-5p/Toll-like receptor 4 (TLR4)/NOD-like receptor protein 3 (NLRP3)/gasdermin D (GSDMD) pathway. Methods: Exosomes... Lire la suite
Arthritis Research & Therapy. Volume 27(1)....
-
Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention
Handgrip strength (HGS) in rheumatoid arthritis (RA) is commonly attributed to joint pathology, but may also reflect extra-articular manifestations, including atrophy of motor-related brain regions. We investigated HGS as a marker of peripheral joint status, systemic immune regulation, and central motor integrity. Methods: Maximal HGS was assessed using a dynamometer. Joint pathology was evaluated... Lire la suite
BMC Medicine. Volume 24(1).
-
The association between Helicobacter pylori and osteoporosis: the mediating effect of inflammation
Osteoporosis, a widespread metabolic bone disorder, leads to diminished bone density, heightened susceptibility to fractures, and overall skeletal fragility. As the world's population continues to age, this condition has emerged as a pressing public health issue. Recent research has explored the possible link between Helicobacter pylori (H. pylori) infection and various systemic... Lire la suite
Gut Pathogens. Volume 18(1).
- Consultez les archives
