À LA UNE de la Rhumatologie
FTY720 Attenuates LPS-Induced Inflammatory Bone Loss by Inhibiting Osteoclastogenesis via the NF-κB and HDAC4/ATF Pathways
In normal bone tissue, homeostasis is maintained by the delicate balance between osteoblast-mediated bone formation and osteoclast- (OC-) mediated bone resorption, and dysregulation of this balance can lead to a variety of skeletal disorders [1, 2]. Excessive OC activation and OC dysfunction disrupt the balance between bone formation and bone resorption, thus leads to increased bone resorption and... Lire la suite
Journal of Immunology Research 2023 (2023),...
Injection of a Bone Substitute in the Treatment of Unicameral Bone Cysts
Simple bone cysts (also known as solitary or unicameral bone cysts) are benign lesions that were first described by Virchow in 1876 . They are fluid-filled, single-chamber lesions situated in the metaphyses of long bones in children and adolescents and constitute approximately 3% of all bone lesions. Although often resolving after skeletal maturity, they predispose children to fractures, can be... Lire la suite
Advances in Orthopedics 2023 (2023), Article...
Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing
Tendon injuries are common musculoskeletal system disorders in orthopedic clinical practices that can cause excruciating pain and disability. Such injuries mostly occur during sports and routine daily activities . The anterior cruciate ligament (ACL) and rotator cuff (RC) are two of the most commonly injured soft tissue structures. The interface where tendons and ligaments attach to the skeleton... Lire la suite
Journal of Nanobiotechnology 2023; 21(1):...
Association between total cholesterol and total bone mineral density in US adults: National Health and Nutrition Examination Survey (NHANES), 2011–2018...
Cholesterol is a major lipid element of human organisms and plays a pivotal role in bile acid metabolism, steroid hormone synthesis, and bone cell metabolism . In the past decades, serum cholesterol is considered being risky in a variety of diseases such as atherosclerosis, Parkinson’s disease, and osteoarthritis [2–4]. Recently, cholesterol toxicity, which globally influences organs,... Lire la suite
Journal of Orthopaedic Surgery and Research...
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