À LA UNE de la Rhumatologie
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Predicting clinical response in psoriatic arthritis through integrative analysis of transcriptomics and proteomics
The therapeutic response to disease-modifying antirheumatic drugs (DMARDs) remains relatively low in psoriatic arthritis (PsA), leading to delayed disease control and frequent treatment switches. Predictive biomarkers may enable personalized treatment and earlier disease control. We aimed to identify transcriptomic and proteomic markers for tofacitinib or comparator treatment outcomes and develop a... Lire la suite
Arthritis Research & Therapy. Volume 28(1)....
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Montelukast suppresses NLRP3 inflammasome activation as a potential prophylactic agent against gout arthritis flares
Gout arthritis (GA) flares are unexpected bouts of heat, swelling, and redness resulting in excruciating pain caused by monosodium urate (MSU) crystal deposition in the synovial joints. GA flare symptoms occur as a by-product of the inflammatory response as immune cells engulf MSU crystals in the joint. The NLRP3 inflammasome is the major source of the inflammatory response to MSU crystals; therefore,... Lire la suite
Journal of Inflammation. Volume 23(1).
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Retinal microvascular changes in patients with ankylosing spondylitis receiving biologic therapy: a cross-sectional OCTA study
To evaluate retinal microcirculation in biologic-treated ankylosing spondylitis (AS) using optical coherence tomography angiography (OCTA) and its association with disease activity. Methods: Fifty-seven AS patients (31 active, 26 inactive) under biologic therapy and 57 age- and sex-matched healthy controls were included. Right eyes underwent 10°×10° macular OCTA imaging (Heidelberg Spectralis).... Lire la suite
BMC Ophthalmology. Volume 26(1).
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Arthroscopic osteosynthesis with demineralized bone matrix and bone marrow aspirated concentrate administration for nonunion of scaphoid in athletes
This study aimed to evaluate the clinical outcomes, with a minimum follow-up of two years, in athletes with scaphoid nonunion and minimal sclerosis who were treated with arthroscopically assisted percutaneous internal fixation augmented by injection of demineralized bone matrix (DBM) and bone marrow aspirate concentrate (BMAC). Method: Between January 2021 and January 2024, a consecutive series of... Lire la suite
BMC Musculoskeletal Disorders. Volume 27(1)....
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