À LA UNE de la Rhumatologie
Potential contributors to low dose methotrexate toxicity in a patient with rheumatoid arthritis and pernicious anemia: case report
Methotrexate (MTX), a folate antagonist, is one of the disease-modifying antirheumatic drugs (DMARD) commonly used in low doses (ranging from 10 to 25 mg weekly) to treat rheumatoid arthritis (RA) and other immune-mediated chronic inflammatory diseases. MTX is generally well tolerated, cost-effective, and highly efficacious at inducing and maintaining remission . However, use-limiting toxicity... Lire la suite
BMC Rheumatology 2020; 5(1): 5
Surgical outcomes of two kinds of demineralized bone matrix putties/local autograft composites in instrumented posterolateral lumbar fusion
Lumbar spinal fusion procedures are usually performed for lumbar degenerative diseases when preoperative instability is present or when postoperative instability is expected due to the extensive decompression required during surgery [1–8]. The ultimate aim of lumbar spinal fusion procedures is to achieve solid fusion at the index level. Ideal graft materials or graft substitutes should have three... Lire la suite
BMC Musculoskeletal Disorders 2021; 22(1):...
Lymphatic muscle cells contribute to dysfunction of the synovial lymphatic system in inflammatory arthritis in mice
Rheumatoid arthritis (RA) is an autoimmune disorder that typically has symptoms of warm, swollen, and painful joints. It is featured by synovitis with infiltration of inflammatory cells, predominance of catabolic factors including pro-inflammatory cytokines and pro-erosive mediators, and the progressive destruction of cartilage and bone. Clinical study reports that lymph drained from RA joints contains... Lire la suite
Arthritis Research & Therapy 2021; 23(1):...
Chronic osteo-articular changes in patients with sickle cell disease
Hemoglobinopathies are a group of diseases of genetic origin in which mutations in the genes encoding hemoglobin (Hb) can result in changes in their synthesis. Most of them comprise qualitative defects that result in the production of different Hb molecules with abnormal structure, resulting in sickle cell disease (SCD), and quantitative defects that affect the synthesis of globin chains, resulting... Lire la suite
Advances in Rheumatology 2021; 61(1): 11
- Consultez les archives